Invivyd is looking to develop and characterize human therapeutic antibody candidates against infectious disease targets like SARS-CoV-2, influenza, and RSV to protect immunocompromised individuals from severe viral infectious diseases.
Requirements
- High proficiency in mammalian cell culture is required.
- Previous experience working with virus in a BSL-2 setting is required.
- Previous experience with cell-based assays and functional antibody characterization is highly preferred.
- Mammalian cell transfection with an understanding of expression vector design is highly preferred.
- Strong understanding of molecular biology and experience with DNA construct design and sequence analysis is highly preferred.
- Ability to interpret in-process readouts for the purposes of assay optimization and troubleshooting.
Responsibilities
- Development and troubleshooting of virus-based antibody screening functional assays and optimization of existing assays.
- Contribute to high-impact projects within the Discovery group by characterizing lead antibody molecules for pre-clinical studies.
- Perform experiments involving in vitro screening and characterization of antibody drug candidates using immunological, biochemical, and cell-based assays.
- Generate pseudoviruses for use in evaluation of antibody candidates.
- Generate authentic viruses in a BSL-2 setting for use in evaluation of antibody candidates.
- Participate in the molecular design and characterization of DNA constructs used for assay development.
- Execute basic molecular biology (DNA manipulation such as RNA extraction, RT-PCR, PCR, cloning, etc.) and Cell Biology (mammalian cell culture, gene transfection and expression) to support antibody discovery efforts.
Other
- Master’s degree or Bachelor’s degree and 4+ years of bench Industry experience in virology, molecular biology, cell biology, or other life science disciplines.
- Proactive team player and flexibility to work on multiple projects as the discovery programs evolve over time.
- Excellent verbal and written technical and non-technical communication skills.
