The Biologics Process Research & Development organization within our company's Research Laboratories is responsible for developing the drug substance manufacturing processes for our company's biologics pipeline. We are seeking a highly motivated and experienced individual to join our Downstream Process Development and Engineering group as an Associate Principal Scientist to design and develop downstream purification processes in support of early and late-stage biological products.
Requirements
- Proven record of accomplishments in downstream process and technology development with a scientific publication and presentation track record.
- Scientific understanding of the engineering principles for recombinant protein purification unit operations.
- Proven ability to design and execute protein purification experiments independently.
- Ability to direct the planning, execution, analysis, and documentation of all stages of downstream process development.
- Knowledge of biologics CMC development cycle
- Demonstrated ability for taking initiative, creativity, and innovation in problem solving
- Experience with high throughput experimentation using automation platforms such as TECAN
Responsibilities
- Leading biologic downstream process development for first-in-human and commercial processes by efficiently developing high yield, robust and scalable processes.
- Independently designing and conducting experiments using relevant operational parameters and analytical inputs.
- Providing technical supervision for process development and characterization
- Collaborate with upstream process development, Biologics Analytical R&D, and other cross-functional teams in both Research and Manufacturing to advance biologics pipeline.
- Advancing downstream platform process technical strategy, and championing creative process improvement initiatives
- Assessing new technologies, sciences, and industry strategies and relevance to our company
- Collaborating with academia, industry partners, and vendors to drive development, innovation and adoption of new process technologies
Other
- Applicants should have effective organizational and multi-tasking skills and strong communication skills both verbal and presentation of data is required.
- A track record of leveraging data science and digital tools for delivering impactful solutions to complex problems are distinguishing.
- Evidence of strong cross-functional collaboration, experience successfully mentoring junior scientists, leading projects, and an external presence through scientific excellence are expected.
- Mentoring junior scientists
- Ability to work in a matrixed team environment and collaborate with both internal and external partners including vendors
