The job is looking to solve the problem of speeding up drug discovery and development to find answers for patients and their families by providing computational chemistry support.
Requirements
- Proficient in the use of modeling techniques (machine learning, and absolute binding free energy calculations, metadynamics and Monte Carlo simulations) and capable of developing and automating workflows.
- Demonstrated skills in developing and implementing AI-based algorithm and method for property predictions.
- Recognized as a technical expert with growing scientific and subject matter expertise and innovative contributions.
- Emerging track record as a contributor providing quality science that forms the basis for publications, presentations and patents and involvement in professional society.
Responsibilities
- Provide computational chemistry support, including cheminformatics, structure and ligand-based hit identification and lead optimization.
- Perform in-depth analysis of project data, such as HTS results, biochemical assay results, biophysical data, and propose new studies and experiments.
- Develop and apply predictive models to support medicinal chemistry efforts in the design and prioritization of novel bioactive compounds based on emerging data.
- Use knowledge and experience to proactively collaborate with other team members to design target compounds which address challenges and/or test a hypothesis.
- Conduct and analyze patent searches, assess the patentability of designed compounds, assist with filing of patent applications.
- Champion new modeling techniques and participate in software evaluation and recommendation.
- Collaborate with data scientist to implement predictive models/tools within informatics platform.
Other
- Master’s degree in physical organic chemistry, biophysics, medicinal chemistry or related field plus 3 years of related experience.
- Understand and articulate the scientific rationale of the project to other scientists.
- Provide formal and informal mentoring of computational tools within project team and medicinal chemists in the department.
- Actively participate in project team meetings, communicate in a clear and precise manner, raise questions, and contribute to the project.
- Work closely with medicinal chemistry & structural biology scientists with shared ownership and accountability of project.
- Communicate and interact with staff members in a professional and courteous manner.
- Adapt to changes and challenges in a productive and professional manner.
- Conduct work according to HSE guidelines and adhere to all mandatory company compliance requirements.
- Act as an ambassador for the department and company, attend appropriate scientific meetings to increase knowledge and stay current with journal and patent literature.
