Prellis Bio is looking to solve long-standing industry-wide problems in the drug development pipeline by combining novel methods in machine learning, biology at scale, and next-gen antibody discovery.
Requirements
- Demonstrated hands-on experience in single B cell sequencing techniques (e.g., 10x Genomics, CITE-Seq, FACS B cells).
- Working knowledge/experience in NGSlibrary prep, QC, and sequencer operation.
- Comfortable working with LIMS/ELN systems, and basic data handling in Excel.
- Direct experience in biotech or academic antibody discovery programs.
- Working knowledge in B cell immunology or antibody biology.
- Familiarity with automated liquid handlers or high-throughput molecular biology workflows.
- Interest in complex data analysis and visualization.
Responsibilities
- Execute and establish high-throughput single B cell VH-VL recovery and NGS workflows (e.g., 10xGenomics, CITE-Seq)from diverse discovery sources, including organoid-derived B cells and immunized animals.
- Perform RNA/DNA extraction, cDNA synthesis, PCR amplification, and NGS library preparation.
- Conduct routine QC of sequencing libraries (Bioanalyzer/TapeStation, Qubit, qPCR) and coordinate sequencing operations with internal and external partners.
- Support antibody sequence/repertoire analysis and report generation.
- Collaborate cross-functionally with biology and expression teams to ensure successful progression of pipeline projects.
- Maintain accurate and complete experimental records in electronic lab notebooks (ELN) and contribute to SOP development and optimization.
- Participate in troubleshooting, continuous improvement, and scalability efforts for high-throughput sequencing pipelines.
Other
- BSc or M.S. in Molecular Biology, Genetics, Biotechnology, or related field with 3+ years of relevant professional experience.
- Strong organizational skills, attention to detail, and ability to work in a fast-paced, team-oriented environment.
- Excellent written and interpersonal communication skills
- Demonstrated experience in working collaboratively across various scientific disciplines
- Good initiative and ability to work independently with minimal supervision
