St. Jude Children's Research Hospital is seeking a skilled and highly motivated wet lab Scientist to contribute to the mission of developing state-of-the-art computational methods for ligand/drug discovery, with a focus on experimental validation of protein-ligand interactions, targeting proteins associated with epigenetic regulation, cancer, and healthy aging/longevity.
Requirements
- Experience in ligand discovery
- Machine learning
- High-performance/cloud computing
- Quantum chemistry and quantum computing
- Biophysical methods (SPR, MST, ITC, BLI)
- Fluorescence-based (i.e. FP, TR-FRET) methods
- Structural studies (NMR, X-ray, cryo-EM, …)
Responsibilities
- Leading the wet lab experiments of our ligand/drug discovery projects with minimal to moderate supervision.
- Protein Production: Express and purify target proteins of interest, predominantly using bacterial expression systems, and in cases needed insect, or mammalian systems.
- Binding Assays: Design and execute ligand-binding experiments, with a focus on biophysical assays and fluorescence-based assays, but also including cell-based assays.
- Wet Lab Leadership/Management: Manage day-to-day operations of the wet lab.
- Identify, process, organize, summarize, review, and report relevant data.
- Interacting with computational team members (who will mostly identify the hit and lead compounds computationally).
- Manuscript preparation, submission, and the review process will be part of the responsibilities (under the supervision of the PI)
Other
- Bachelor's degree in relevant scientific area is required.
- Eight (8) years of relevant work experience is required with a Bachelor's degree.
- Six (6) years of relevant work experience is required with a Master's degree.
- Three (3) years of relevant work experience is required with a PhD.
- Mentoring and training wet lab members, including postdocs, graduate students, and technicians.
