Generate:Biomedicines is seeking to support its high throughput (HTP) protein characterization effort by hiring an individual to work cross-functionally with various teams to advance portfolio programs.
Requirements
- Protein characterization via chromatography (affinity, RP, HIC, IEX and SEC via FPLC, HPLC, UHPLC, UPLC, nanoUPLC), electrophoresis (r/nrCE-SDS, cIEF, SDS-PAGE, native PAGE), sizing (SEC-MALS, DLS), viscometry and particle analyses (HIAC, MFI)
- Protein therapeutics developability assessments
- HTP plate-based assays (eg: ELISA)
- Experience in mass spectrometry and protein chemistry is a plus.
- Training or practical experience in the above listed techniques.
Responsibilities
- Complete training to independently execute state-of-the-art HTP methods, including but not limited to various chromatography methods (affinity, RP, HIC, IEX and SEC via FPLC, HPLC, UHPLC, UPLC, nanoUPLC), electrophoresis (r/nrCE-SDS, cIEF, SDS-PAGE, native PAGE), sizing (SEC-MALS, DLS), viscometry and particle analyses (HIAC, MFI).
- Conduct long-term developability assessment and formulation screening using a wide collection of analytical techniques.
- If required, perform new methodologies to stress proteins for characterizations of post-translational modifications (PTMs) of interest.
- Develop new methods to expand on the analytical workflows in-house.
- Analyze and cross-functionally communicate analytical data.
- Draft internal operational protocols and external publications.
- Cross-train colleagues within or outside the group as a subject-matter expert.
Other
- MSc degree in a related field, or a BSc degree with 2+ years of related experience (industry preferred).
- Qualified candidates with a BSc degree and<2 years of experience will be considered at the Research Associate I level.
- An educational background in protein chemistry, biochemistry or biophysics is strongly preferred.
- Excellent attention to detail and documentation skills.
- Outstanding communication skills, transparency and respect for others.
