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Full Stack - Principal Software Engineer, Drug Discovery

Genentech

$155,500 - $288,900
Aug 22, 2025
South San Francisco, CA, US
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Roche's Research and Early Development organisations at Genentech (gRED) and Pharma (pRED) need to accelerate R&D by leveraging data and novel computational models. The new Computational Sciences Center of Excellence (CoE) aims to harness the transformative power of data and Artificial Intelligence (AI) to assist scientists in delivering more innovative and transformative medicines.

Requirements

  • 10 + years of software engineering work experience, delivering complex, full-stack applications.
  • Proven expertise in front-end development using modern frameworks (e.g., React, Angular) and building intuitive, user-centered interfaces.
  • Proficiency with Python and SQL
  • Familiarity with ML concepts or frameworks (e.g., PyTorch).
  • Domain experience in drug discovery, computational biology, bioinformatics and cheminformatics

Responsibilities

  • Contribute to the strategic roadmap for the Prescient "Lab-in-the-Loop" platform, guiding product features and technical architecture to maximize AI impact in drug discovery.
  • Take a leading role in the full-stack design and development of scalable, reliable software systems, including crafting responsive and intuitive front-end applications that form the core of our AI/ML platform.
  • Collaborate closely with Machine Learning Scientists, AI Engineers, and experimental specialists, translating complex scientific workflows into intuitive user interfaces, dashboards, and analytics tools with a strong focus on user experience.
  • Explore and implement integrations with novel AI agents and models to enhance platform capabilities and automate complex tasks.
  • Mentor and provide technical guidance to other software engineers on the team, fostering best practices and high-quality engineering.

Other

  • Intense curiosity about the biology of disease and eagerness to contribute to scientific and computational efforts.
  • Relocation benefits are available for this job posting
  • The expected salary range for this position, based on the primary location of New York is $155,500 - 288,900.
  • A discretionary annual bonus may be available based on individual and Company performance.
  • This position also qualifies for the benefits detailed at the link provided below.