Retro develops therapies for diseases driven by the biology of aging, aiming to add 10 years to healthy human lifespan. This role specifically supports the development of rejuvenation therapies for osteoarthritis (OA).
Requirements
- Have proven experience designing, leading, and conducting in vivo experiments.
- Have prior research experiences in musculoskeletal biology and osteoarthritis research.
- Hands-on experience in drug dosing, microsurgical model generation for osteoarthritis, histology, immunohistochemistry, and/or immunofluorescence.
- Are experienced in analyzing and quantifying histological and imaging data.
- Have expertise in structural damage assessment, including histopathology (e.g., OARSI scoring) and advanced imaging modalities.
- Are familiar with behavioral and functional assessments relevant to OA (e.g., weight bearing, gait analysis).
- Have prior experience in gene therapy development
Responsibilities
- Support the development of the osteoarthritis (OA) research pipeline, working collaboratively with in vitro focused team members.
- Drive in vivo side of the program, including designing and executing OA studies with either healthy animals or disease models, performing drug administration, histological analysis, and comprehensive characterization (biodistribution, gene expression profiling, PK/PD, and toxicology).
- Perform and train technical in vivo team members on surgical induction of osteoarthritis models in mice and rats.
- Conduct intra-articular (IA) injections for therapeutic delivery.
- Collaborate with cross-functional teams (Vivarium, Computational biology) to integrate preclinical findings.
- Maintain accurate records and protocols, analyze and interpret experimental data; provide scientific and development insights and in-depth data interpretation to inform decision-making within the team and for senior leadership.
- Work with other departments and CROs as necessary to plan and expedite project objectives.
Other
- You have a good understanding of Musculoskeletal biology and have hands-on experience in related histology.
- You enjoy hands-on work and value being organized, planning proactively, and paying attention to the details.
- You’re a highly collaborative team member with a “can-do” attitude and you apply a “Mission > team > individual" mindset to your work.
- You value direct, clear communication.
- You’re motivated to work on a forefront of science and produce therapies that improve patients’ health span!
