Natera is looking for a Lead Biostatistician to drive the design, analysis, and reporting across multiple oncology clinical trials within their ctDNA diagnostic portfolio, aiming to improve the standard of care for personalized genetic testing and diagnostics.
Requirements
- Minimum 5 years relevant clinical biostatistics experience, preferably in oncology, diagnostics, or related biotech/pharma fields.
- Minimum 4 years practical experience with statistical analysis software such as R (preferred) or SAS.
- Expert knowledge of probability theory and statistics including the ability to produce novel methods based on first principles understanding
- Solid foundation in clinical trial design approaches, regulatory expectations, and industry-aligned best practices
- Experience with complex clinical study designs, sample size determination, and advanced analytical methods, including non-inferiority and adaptive trial designs
- Familiarity with incorporating biomarker endpoints into trial design
Responsibilities
- Provide technical leadership in the design, execution, and analysis of oncology clinical utility studies, including endpoint selection, sample size estimation, and methods strategy.
- Execute statistical analyses according to plans and protocols, as well as exploratory or ad-hoc investigations.
- Contribute to protocols, statistical analysis plans (SAPs), tables/figures/listings (TFLs), and study reports.
- Apply emerging or advanced statistical methods where appropriate.
- Contribute to the improvement of internal tools, templates, and statistical best practices.
- Act as the statistical representative on project teams.
- Partner with clinical, translational, and medical teams to align study designs with clinical research objectives.
Other
- Demonstrated proficiency and enthusiasm for working in fast-paced, cross-functional environments with collaborators from diverse technical backgrounds
- Proven ability to independently develop high-quality, audience-tailored documentation that clearly communicates complex scientific and statistical concepts
- Excellent collaboration skills.
- Proactive mindset.
