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Lead Research Engineer / Scientist, Chemical & Biological Risk

Open AI

Salary not specified
Sep 23, 2025
San Francisco, CA, US
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OpenAI is looking to prevent severe chemical and biological misuse across its products by designing, implementing, and overseeing an end-to-end mitigation stack.

Requirements

  • Bring demonstrated experience in deep learning and transformer models.
  • Are proficient with frameworks such as PyTorch or TensorFlow.
  • Possess a strong foundation in data structures, algorithms, and software engineering principles.
  • Are familiar with methods for training and fine-tuning large language models, including distillation, supervised fine-tuning, and policy optimization.
  • Bring background knowledge in biosecurity, computational biology, or adjacent technical fields.

Responsibilities

  • Lead the full-stack mitigation strategy and implement solutions for biological and chemical misuse—from prevention to enforcement.
  • Ensure safeguards integrate seamlessly across OpenAI products and scale with usage.
  • Make decisive calls on technical trade-offs within the bio risk domain.
  • Partner with risk modeling leadership to align mitigation design with anticipated risks and coverage.
  • Drive rigorous safeguard testing by stress-testing the mitigation stack against evolving threats and product surfaces.

Other

  • Have a passion for AI safety and are motivated to make cutting-edge AI models safer for real-world use.
  • Excel at working collaboratively with cross-functional teams across research, policy, product, and engineering.
  • Show decisive leadership in high-stakes, ambiguous environments.
  • Have significant experience designing and deploying technical safeguards at scale.