The Khan Lab at Stanford University is investigating RNA folding, RNA–protein interactions, and their cellular consequences using an interdisciplinary approach. They are seeking an experimental research associate to help establish laboratory procedures, drive experimental projects, and support the day-to-day operations of a growing group.
Requirements
- Experience with molecular and cell biology techniques; strong preference for RNA biochemistry (e.g., in vitro transcription, RNA handling, nuclease assays) and/or protein purification.
- Experience with electron microscopy (cryo-EM/ET) workflows and/or structural biology is a plus.
- Familiarity with quantitative data analysis; comfort collaborating with ML/comp teams is welcome.
- General understanding of scientific principles. Demonstrated performance to use knowledge and skills when needed.
- Demonstrated ability to apply theoretical knowledge of science principals to problem solve work.
- Ability to maintain detailed records of experiments and outcomes.
- General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
Responsibilities
- Reconstitution and biochemical/biophysical characterization of RNA–protein complexes.
- Sample preparation for cryo-EM/ET of RNA and RNP assemblies in vitro and (where appropriate) in cells.
- Cell-based assays to test how RNA structure and RBP interactions influence phenotypes in viral and cellular systems.
- Coordinating with computational collaborators to integrate ML predictions with experimental design and validation.
- Independently conduct experiments; maintain detailed records of procedures, data, and outcomes.
- Apply life-science methods to analyze results; recommend protocol optimizations in collaboration with senior researchers.
- Stay current with the literature and apply relevant advances to ongoing projects.
Other
- High initiative, strong organization and time-management, excellent communication, and a collaborative mindset.
- Prior lab management experience (safety, inventory, ordering, equipment maintenance) is highly desirable.
- Assist with orientation and training of new staff or students on lab procedures and techniques.
- Ability to work under deadlines with general guidance.
- Excellent organizational skills and demonstrated ability to accurately complete detailed work.
