Recursion is looking to characterize network dysfunction in neurodegenerative disease models by applying expertise in advanced electrophysiology and neuropharmacology to generate high-quality data that will fuel their discovery pipeline and advance new medicines.
Requirements
- Direct hands-on experience with functional neuroscience techniques such as multielectrode arrays and other high-throughput ephys platforms to characterize drug candidates and profile novel cellular model systems.
- Hands-on expertise and proficiency with human cell-based translatable systems, including iPSC-derived neurons and 2D or 3D in vitro neurodegenerative disease models.
- Demonstrated ability to independently design, optimize, analyze and present data related to cell-based functional assays.
- Deep experience with electrical traces, local field potentials (LFP), or calcium imaging is highly desirable.
- Experience with basic coding (e.g., Python, R, MATLAB) and neural signal processing is preferred.
- Knowledge and ability to execute general molecular biology techniques and assays for downstream protein and RNA processing preferred.
- Applying your deep expertise in advanced electrophysiology and neuropharmacology to characterize network dysfunction in neurodegenerative disease models.
Responsibilities
- Serve as a hands-on technical expert, executing advanced neuropharmacology and electrophysiology studies (e.g., multielectrode arrays, imaging assays) on human iPSC-derived neurons and 2D/3D neurodegenerative disease models.
- Independently design, develop, and optimize cell-based functional assays to characterize drug candidates and profile new model systems.
- Conduct rigorous analysis, signal processing, and troubleshooting of complex neuroscience datasets (e.g., electrical traces, local field potentials, calcium traces, pharmacodynamic modeling).
- Document and present experimental designs, data, and actionable insights to our cross-functional team to help drive program decisions.
- Manage key laboratory functions with high attention to detail, including coordinating any cross-functional lab work, monitoring inventory, ordering reagents, and basic equipment maintenance.
- Be a key hands-on contributor to our neuroscience team, applying your deep expertise in advanced electrophysiology and neuropharmacology to characterize network dysfunction in neurodegenerative disease models.
- Generate high-quality, actionable data that our entire programs will build on. You'll use your skills with cellular models, including human iPSC-derived 2D and 3D models, to produce the functional readouts (e.g., MEA, calcium imaging and other neuropharmacology assays) that fuel our discovery pipeline.
Other
- M.S. or B.S. in Neuroscience, Biology, or related field (Ph.D. not required) and 3–5 years of pharmaceutical or biotechnology experience with hands-on execution of advanced cellular neuropharmacology and electrophysiological studies, preferably within the context of neurodegenerative diseases.
- Collaborate closely with a cross-functional team of biologists and data scientists.
- Help our team grow and improve by bringing your pharma expertise and rigorous, detail-oriented approach to the lab.
- Contribute to a fast-paced, mission-driven environment where your ability to troubleshoot, communicate clearly, and work as part of a team is essential to our collective success.
- Employees are expected to work in the office/lab at least 80% of the time.
