Pioneering Medicines is seeking to harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner, by driving translational efforts across multiple therapeutic areas and drug modalities.
Requirements
- Understanding of translational research including biomarker discovery, PK/PD/efficacy relationships, dose predictions, and supporting assets into early clinical development.
- Experience in target validation and identifying targets with strong causal human biology.
- Well-versed in various biochemical, cellular, and immunological techniques in the laboratory.
- Experience developing proof-of-concept for novel biomarker assays, suitable for implementation on early phase clinical trials.
- Scientific expertise in immunology, liver disease, cardio/renal/metabolic and/or oncology.
- Ability and interest to work across multiple therapeutic areas and modalities.
- A strong understanding of translational bioinformatics is highly desirable.
Responsibilities
- Generate and interpret translational data to support biomarker discovery, PK/PD and dose predictions, standard-of-care benchmarking, and development of clinically applicable biomarker assays.
- Develop platforms, identify CROs and external collaborators to grow the translational sciences capabilities.
- Opportunity to serve as scientific lead on early discovery projects, guiding cross-functional integration and strategy.
- Leverage translational datasets to identify new targets for early discovery.
- Provide scientific mentorship and training to junior staff, and contribute to the operational strategy of the research team.
- Ability to establish novel protocols or techniques in the lab or at CROs, and to train and mentor junior team members for data delivery.
- Ability to leverage cross-functional approaches to derive translational insights.
Other
- Ph.D., with 2+ years or MSc with 5+ years, including some industry experience (or equivalent).
- Ability to work onsite at our Cambridge, MA site.
- Experience engaging with key opinion leaders and participating in external scientific collaborations.
- Demonstrate an insatiable curiosity, strong work ethic, and the ability to work equally well in a team or independently.
- Most importantly, curious and a positive, problem-solving can-do attitude.
