Mass General Brigham is seeking a Postdoctoral Fellow to lead computational efforts focused on AI-accelerated drug discovery and delivery for neurological diseases. The role aims to develop and apply machine learning methods to integrate complex biological data, identify therapeutic targets, and design novel compounds to combat neurodegeneration.
Requirements
- PhD in Computational Biology, Bioinformatics, Machine Learning, Computer Science, Statistics, or a related field (recently completed or near completion).
- Strong publication record demonstrating expertise in ML applied to biology.
- Expertise in Python; experience with deep learning frameworks (PyTorch/TensorFlow); single-cell genomics analysis (Seurat, Scanpy, scVI, etc.); and perturbation modeling (e.g., GEARS, scGen).
- Experience with biological foundation models (e.g., scGPT, Geneformer, scBERT); generative AI for sequences/proteins/peptides (e.g., RFdiffusion variants); cheminformatics tools (e.g., RDKit, PubChem querying); active learning/uncertainty quantification; pipeline automation (e.g., custom scripts or Airflow); integration of public resources (e.g., OpenTargets, ChEMBL); or basic computational ADMET/pharmacokinetics assessment.
- Background in neurodegenerative disease.
- Wet lab skills in molecular and cellular biology, nanotechnology, and pharmacology.
Responsibilities
- Integrate multimodal data and develop and train AI foundation models on large-scale biological datasets for predictive modeling of cellular responses, target identification, and drug candidate identification.
- Apply generative and sequence-based ML models to design, model, and optimize binding peptides.
- Analyze high throughput screens and biological datasets to inform in silico predictions.
Other
- Excellent organizational, communication, and teamwork abilities in a fast-paced research environment.
- Interest in translational impact.
- Onsite work location.
- All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law.
- Individuals with a disability will be provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
