The Pottier Laboratory at WashU Medicine aims to identify disease-associated events for therapeutic targets and biomarkers for early-onset dementia, such as early-onset Alzheimer's disease and frontotemporal dementia. This role will leverage comprehensive genomic, transcriptomic, and proteomic analyses to discover pathways related to disease presentation.
Requirements
- Solid skills in at least one programming language (R, python, or Perl) and experience working in Linux and/or high-performance cluster environments.
- A strong ability to perform analytical reasoning to extract biological insights from data-driven approaches.
- Familiarity with interrogation of publicly available resources (highly beneficial).
- Familiarity with genetics of neurodegenerative disorders.
- Practical experience with PLINK, SKAT, Seurat, or similar gene-based association tools.
- Proficiency in conducting association studies and/or single nuclei RNA sequencing analyses.
- Bioinformatics, Computer Science, Data Analysis, GATK, Genetic Research, Genome Sequencing, Linux, Neurodegeneration, PLINK (Software), Python (Programming Language), Statistical Genomics
Responsibilities
- Assists with grant preparation and reporting.
- Prepares and submits papers on research.
- Assists in the design of research experiments.
- Evaluates research findings and assists in the reporting of the results.
- Conscientious discharge of their research responsibilities.
- Maintains conformity with ethical standards in research.
- Maintains compliance with good laboratory practice including the maintenance of adequate research records.
Other
- Trains under the supervision of a faculty mentor.
- Engages in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
- Collegial conduct towards co-trainees, staff members and members of the research group.
- Adherence to all applicable University policies, procedures and regulations.
- Ph.D., M.D. Or Equivalent Terminal Or Doctoral Degree.
