Investigating mechanisms of treatment resistance in gastrointestinal cancers, with a specific emphasis on pancreatic neuroendocrine and biliary tract cancers and exploring the roles of KRAS pathway inhibition and inflammatory pathways mediated by TNF, TGF-β, and the IL-1R/TLR axis. The overarching goal of our research is to develop novel therapeutic regimens that can be advanced into clinical trials for cancer patients.
Requirements
- Proficiency in molecular biology techniques including western blots, cell cultures, molecular cloning, PCR and other typical wet bench techniques
- Experience and be comfortable with handling experimental and transgenic mouse models
- Data Analysis
- Data Interpretations
- Experimentation
- Flow Cytometry
- Immunohistochemistry (IHC)
Responsibilities
- Conducting experiments using basic bench techniques
- Performing assays such as western blots, cell cultures, and molecular cloning
- Analyzing genomic and transcriptomic datasets with help from bioinformatician already in the lab
- Develops expertise in molecular biology and tumor immunology
- Assists in the design of research experiments
- Evaluates research findings and assists in the reporting of the results
- Maintains conformity with ethical standards in research
Other
- Ph.D. in a relevant field
- Manages their own project, which should lead to a first author publication.
- Develops proficiency in career skills, including writing, public speaking, networking, and critical evaluation of scientific literature.
- Presents scientific work both inside and outside the University with excellent oral communication skills.
- Maintains compliance with good laboratory practice including the maintenance of adequate research records.
