The Arc Institute is seeking to understand and treat complex human diseases by conducting curiosity-driven basic science and technology development. The Arce Lab specifically aims to identify and correct the origins of immune-mediated disease by investigating the regulatory mechanisms required for distinct immune functions.
Requirements
- Experience with CRISPR gene editing and high throughput screening
- Proficiency in coding languages such as R or Python for genomic data analysis
- Experience with immune cell culturing and immunological functional assays
- Ability to work independently to establish new technical protocols and derive biological insight from findings
Responsibilities
- Adapt and integrate cutting edge gene editing techniques and genomic assays to investigate the genetic origins of autoimmune diseases.
- Design and execute experiments aimed at understanding how dysfunction occurs at a cellular level.
- Investigate the role of autoimmune risk variants on cellular functions.
- Apply CRISPR genome editing in primary human immune cells.
- Generate and analyze single cell multi-omics data.
- Collaborate both internally and with external institutions to pursue the biochemical mechanism of specific regulatory factors.
- Communicate your work in the form of publications and presentations.
Other
- PhD in immunology, genomics, genetics, biological sciences or related fields
- Highly collaborative team player willing to both learn from and train others
- Resourceful and eager to push forward progress
- Excellent written and verbal communication skills
- Participate in lab meetings and Institute-wide activities (seminars, symposiums, etc).
