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Principal Applied Scientist

Microsoft

$139,900 - $304,200
Aug 27, 2025
Redmond, WA, US
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The Business and Industry Solutions (BIS) team is looking for a Principal Applied Scientist to drive innovation at the intersection of AI, experimentation, and enterprise systems, aiming to shape the future of the autonomous enterprise and lead the development of intelligent, agent-first experiences that transform how businesses operate.

Requirements

  • Prior expertise in natural language processing (NLP), with a strong foundation in large language model (LLM) development, evaluation, and fine-tuning.
  • Hands-on experience in applying advanced fine-tuning techniques—including instruction tuning, reinforcement learning from human feedback (RLHF), and tool-augmented generation—to build agents capable of multi-step reasoning and decision-making.
  • Familiarity with prompt/context engineering, context-aware orchestration, and integrating LLMs with external tools and APIs is essential.
  • Comfortable working in a fast-paced, experimentation-driven environment, leveraging both offline and online evaluation methods to iterate rapidly and optimize agent behavior.
  • 5+ years experience developing and deploying AI/ML products or systems at multiple points in the product cycle from ideation to shipping.

Responsibilities

  • Design and evaluate autonomous agents that deliver measurable improvements in accuracy, latency, and cost-efficiency.
  • Lead rapid experimentation cycles, develop robust evaluation frameworks, and apply advanced techniques like reinforcement learning to enable multi-step reasoning and decision-making.
  • Collaborate across engineering, product, and partner teams to ensure agents are performant, secure, reliable, and extensible—empowering customers and partners to build on our platform.
  • Lead the development and deployment of advanced model fine-tuning pipelines, leveraging Reinforcement Learning from Human Feedback (RLHF) to align AI system behavior with human intent and improve performance in complex, real-world enterprise scenarios.
  • Design and implement robust measurement systems, experimentation frameworks, and causal inference methodologies tailored to dynamic AI systems and enterprise-scale environments.
  • Harness AI to accelerate workflows and amplify team productivity through intelligent automation and innovation.

Other

  • Ability to meet Microsoft, customer and/or government security screening requirements are required for this role.
  • Microsoft Cloud Background Check This position will be required to pass the Microsoft Cloud background check upon hire/transfer and every two years thereafter.
  • Drive strategic impact by identifying and leading high-leverage data science and analytics initiatives across multiple product domains.
  • Guide strategic direction and investment decisions by owning complex, end-to-end projects that blend technical depth with organizational influence.
  • Build alignment and trust across leadership and cross-functional teams through clear, persuasive communication and collaborative engagement.