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Principal Applied Scientist

Microsoft

$139,900 - $304,200
Oct 2, 2025
Remote, US
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Microsoft is looking to drive innovation at the intersection of vibe coding, low code, and Copilot by developing AI-native business applications that enable multi-step reasoning and decision-making, empowering customers and partners to build on their platform.

Requirements

  • Prior expertise in natural language processing (NLP).
  • Strong foundation in large language model (LLM) development, evaluation, and fine-tuning.
  • Experience in applying advanced fine-tuning techniques—including instruction tuning, reinforcement learning from human feedback (RLHF), and tool-augmented generation—to build agents capable of multi-step reasoning and decision-making.
  • Familiarity with prompt engineering, context-aware orchestration, and integrating LLMs with external tools and APIs is essential.
  • Comfortable working in a experimentation-driven environment.
  • Deep understanding of the challenges and opportunities in building AI-native enterprise applications will be key to success in this role.

Responsibilities

  • Lead rapid experimentation cycles, develop robust evaluation frameworks, and apply advanced techniques like reinforcement learning to enable multi-step reasoning and decision-making.
  • Collaborate across engineering, product, and partner teams to ensure agents are performant, secure, reliable, and extensible.
  • Develop robust evaluation frameworks.
  • Apply advanced techniques like reinforcement learning to enable multi-step reasoning and decision-making.
  • Apply advanced fine-tuning techniques—including instruction tuning, reinforcement learning from human feedback (RLHF), and tool-augmented generation—to build agents capable of multi-step reasoning and decision-making.
  • Leverage both offline and online evaluation methods to iterate rapidly and optimize agent behavior.

Other

  • Bachelor's Degree in Statistics, Econometrics, Computer Science, Electrical or Computer Engineering, or related field AND 6+ years related experience (e.g., statistics, predictive analytics, research) OR Master's Degree in Statistics, Econometrics, Computer Science, Electrical or Computer Engineering, or related field AND 4+ years related experience (e.g., statistics, predictive analytics, research) OR Doctorate in Statistics, Econometrics, Computer Science, Electrical or Computer Engineering, or related field AND 3+ years related experience (e.g., statistics, predictive analytics, research) OR equivalent experience.
  • 5+ years experience creating publications (e.g., patents, libraries, peer-reviewed academic papers).
  • Ability to meet Microsoft, customer and/or government security screening requirements are required for this role.
  • Microsoft Cloud Background Check
  • 2+ years experience presenting at conferences or other events in the outside research/industry community as an invited speaker.