Flagship Labs 101 is looking to build a discovery engine that will map and control cellular interactions to discover novel targets and transform the lives of patients.
Requirements
- Proficiency in Python (pandas, NumPy, scikit-learn; Scanpy) and R (Seurat, Bioconductor) for single-cell analysis; SQL for data manipulation.
- Experience with spatial transcriptomics and perturb-seq/CRISPR screening, including analysis and subsequent experimental design.
- Experience in drug discovery with a focus on therapeutic target identification/prioritization and support for functional validation.
- Demonstrated experience taking single-cell/spatial analyses from raw data to target nomination (e.g., marker/driver identification, pathway/ligand-receptor analyses, stratification, and biomarker hypotheses).
- Strong foundation in experimental design, statistical inference, multivariate analysis, and integration of orthogonal evidence (e.g., human genetics, proteomics, imaging).
Responsibilities
- Lead routine and novel analysis of sequencing-based data from FL101’s platform.
- Contribute to analysis pipelines using best-in-class methods
- Collaborate with computational and experimental teams to integrate analytical outputs, prioritizing experiments and follow-up functional assays.
- translate scientific questions into data requirements and modeling strategies
- Continue best practices for code versioning, data provenance, reproducibility, and analysis notebooks; contribute to internal knowledge bases and publications.
- Support external partnerships
Other
- Ph.D. (or equivalent experience) in Computational Biology, Data Science, Statistics, Machine Learning, or related quantitative field.
- 6+ years post-degree (industry or equivalent), with expertise in single-cell analysis for target discovery.
- Track record of cross-functional collaboration and scientific communication to non-experts.
- Experience working in a matrix organizational structure; comfort mentoring and providing technical direction.
- The ideal teammate will be highly adaptable, an excellent communicator, and thrive in a collaborative, multidisciplinary environment.
