GSK is looking to hire an Oligotherapy Principal Data Scientist to support the Oligo Sciences team in the design, characterization, and early development of oligonucleotide therapies. The role involves co-developing a data capture & analysis platform and building methods/models/capabilities to translate scientific needs across GSK.
Requirements
- Minimum of 1 year experience with genomic data infrastructure for either public or private collections (e.g. ENCODE, TCGA, DepMap, GTEx, cellXgene, UK biobank.
- Minimum of 1 year experience with Cheminformatic or structural modelling of drug-target binding for small or large molecules validated by real qSAR assays.
- Performed target identification or tractability/prioritization for RNA-modulating approaches or RNA-targeted modalities.
- Participated in high-throughput or high-content screening for hits followed by low-latency iterations for lead optimization.
- Developed analytic tools & data pipelines for processing & querying large batches of disease/perturbation/control samples.
- Mastery of statistical learning or predictive modelling with signals and noise in empirical datasets: either observational or perturbational
- Mastery of predictive analytics and modern data stack: principal developer on a codebase in Python/R/Julia/C++/Java/Rust, or considerable and consistent contributions to an open-source project, or Top10 placement in life-science-themed competitions on Kaggle/TopCoder/DREAM challenge.
Responsibilities
- Co-design and implement a target tractability system for oligo-guided therapeutic mechanisms such as RNA degradation/interference, and up/down modulation of alternative splicing, poly-adenylation, A>I edit, etc.
- Co-develop a target/complex engagement model that combines target sequence, secondary+ tertiary structure, and oligo chemistry to drive binding assay designs for both high-throughput screening and low-latency optimization.
- Collaborate effectively with renowned GSK experts in genetics, genomics, computational bio & chem, structural biology and medicinal chemistry, artificial intelligence / machine learning, and digital technologies to build the datasets, tools, models, and infrastructure necessary for oligo design & development.
Other
- PhD degree in computational life science (bio/med/chem/stats/informatics) with minimum of 1 year published work.
- Minimum of 2 years’ experience Post Doctoral or Pharmaceutical Industry experience.
- On-site presence of 2-3 days per week on average required.
- Demonstrated cross-functional communication, matrixed collaboration, both team and thought leadership.
- Biology research focus on either coding or non-coding RNA and its post-transcriptional regulation in various eukaryotic cells/tissues
