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Principal Machine Learning Engineer

Microsoft

$139,900 - $274,800
Dec 18, 2025
Redmond, WA, US
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Health Futures at Microsoft is seeking to advance next-generation AI tools and methods for health and life sciences by accelerating the training of generative models in collaboration with ML researchers, software engineers, and domain experts.

Requirements

  • Bachelor's Degree in Computer Science or related technical field AND 6+ years technical engineering experience with coding in languages including, but not limited to, C++, C-Sharp, Java, JavaScript, or Python OR equivalent experience.
  • Masters in Computer Science or related technical field AND 6+ years technical engineering experience including significant work in machine learning or applied AI OR equivalent experience.
  • Proven track record of designing and deploying large-scale ML or MLops systems in research or product settings.
  • Hands-on experience with large-scale distributed training of ML models.
  • Deep expertise in ML algorithms, model optimization, and frameworks (e.g., PyTorch, TensorFlow).
  • Experience with one or more of: optimizing data mixes, mid-training, post-training, model merging, or model distillation.
  • Familiarity with security and compliance standards for enterprise and health data.

Responsibilities

  • Lead the design and development of machine learning models and systems for health and life sciences applications, ensuring scalability and reliability.
  • Define technical strategy and architecture for ML pipelines, including data ingestion, feature engineering, model training, evaluation, and deployment.
  • Collaborate with interdisciplinary teams (including scientists, researchers, and software engineers) to envision and develop AI-augmented scientific systems.
  • Mentor engineers and researchers, promoting best practices in ML development, experimentation, and responsible AI principles.
  • Ensure security, privacy, and regulatory compliance across ML workflows and data handling.
  • Work across the stack from curriculum design, to debugging training runs, through developing new evaluation methods and high-performance inferencing.
  • Train and optimize models on the latest hardware, devise new ways to assess their capabilities, and evolve data and training workflows to maximize model utility.

Other

  • Bachelor's Degree in Computer Science or related technical field AND 6+ years technical engineering experience OR equivalent experience.
  • Masters in Computer Science or related technical field AND 6+ years technical engineering experience including significant work in machine learning or applied AI OR equivalent experience.
  • Demonstrated ability to communicate effectively and solve problems in collaborative, research-driven environment.
  • Ensure regulatory compliance across ML workflows and data handling.
  • Mentor engineers and researchers, promoting best practices in ML development, experimentation, and responsible AI principles.