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Principal Software Engineer

Microsoft

$139,900 - $304,200
Oct 30, 2025
Burlington, MA, US
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Microsoft's Health and Life Sciences team aims to create an efficient and connected healthcare ecosystem built on the Microsoft Cloud. The HLS Platform team is seeking a Principal Software Engineer to reduce clinician effort and enhance patient outcomes by integrating AI into daily workflows with minimal friction.

Requirements

  • Proven experience in designing, developing, and operating distributed systems and/or services in the cloud.
  • Understanding of AI technologies / models and fundamentals.
  • Proven ability to tackle complex technical issues when running large scale cloud services.
  • Experience with implementing, monitoring and operating software employing Gen AI.

Responsibilities

  • Lead the design and development of AI-integrated services that streamline clinician workflows.
  • Collaborate across teams to ensure production-grade quality, scalability, and security in healthcare solutions.
  • Apply software design principles, managing live site operations, and contributing to cross-team initiatives that deliver impactful AI-centric services for both internal and external Microsoft customers.
  • Integrate advanced AI capabilities into clinician workflows, leveraging Microsoft’s AI ecosystem and trusted third-party solutions to deliver real-world value in healthcare settings.
  • Lead architecture discussions, create proposals, and work together with other team members.
  • Ensure system architecture meets security and compliance requirements while taking observability, reliability and global scaling into account.
  • Own delivery of new features and services end-to-end, including relevant cloud infrastructure changes.

Other

  • Ability to meet Microsoft, customer and/or government security screening requirements.
  • Microsoft Cloud Background Check: This position will be required to pass the Microsoft Cloud background check upon hire/transfer and every two years thereafter.
  • This position requires verification of citizenship due to citizenship-based legal restrictions.
  • Partners with appropriate stakeholders to determine user requirements and incorporate insights into designs.
  • Embody our culture and values.