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Principle Applied Scientist

Microsoft Innovation Center

$139,900 - $304,200
Nov 16, 2025
Redmond, WA, United States of America
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Microsoft's Business and Industry Solutions (BIS) team is seeking a Principal Applied Scientist to drive innovation in AI, experimentation, and enterprise systems, aiming to design and evaluate autonomous agents that deliver measurable improvements in accuracy, latency, and cost-efficiency for businesses.

Requirements

  • Prior expertise in natural language processing (NLP), with a solid foundation in large language model (LLM) development, evaluation, and fine-tuning.
  • Hands-on experience in applying advanced fine-tuning techniques—including instruction tuning, reinforcement learning from human feedback (RLHF), and tool-augmented generation—to build agents capable of multi-step reasoning and decision-making.
  • Familiarity with prompt engineering, context-aware orchestration, and integrating LLMs with external tools and APIs is essential.
  • Comfortable working in a experimentation-driven environment, leveraging both offline and online evaluation methods to iterate rapidly and optimize agent behavior.
  • A deep understanding of the challenges and opportunities in building AI-native enterprise applications will be key to success in this role.
  • 5+ years experience developing and deploying AI/ML products or systems at multiple points in the product cycle from ideation to shipping.
  • 5+ years experience creating publications (e.g., patents, libraries, peer-reviewed academic papers).
  • 3+ years experience developing and deploying live production systems at multiple points in the product cycle from ideation to shipping.

Responsibilities

  • Design and evaluate autonomous agents that deliver measurable improvements in accuracy, latency, and cost-efficiency.
  • Lead rapid experimentation cycles, build robust evaluation frameworks, and apply advanced techniques such as reinforcement learning to enable multi-step reasoning and decision-making.
  • Collaborate across engineering, product, and partner teams to ensure agents are performant, secure, reliable, and extensible—empowering customers and partners to build on our platform.
  • Drive strategic impact by identifying and leading high-leverage data science and analytics initiatives across multiple product domains.
  • Lead the development and deployment of advanced model fine-tuning pipelines , leveraging Reinforcement Learning from Human Feedback (RLHF) to align AI system behavior with human intent and improve performance in complex, real-world enterprise scenarios.
  • Design and implement robust measurement systems , experimentation frameworks, and causal inference methodologies tailored to dynamic AI systems and enterprise-scale environments.
  • Harness AI to accelerate workflows and amplify team productivity through intelligent automation and innovation.

Other

  • Ability to meet Microsoft, customer and/or government security screening requirements are required for this role.
  • Microsoft Cloud Background Check: This position will be required to pass the Microsoft Cloud background check upon hire/transfer and every two years thereafter.
  • Steer strategic direction and investment decisions by owning complex, end-to-end projects that blend technical depth with organizational influence.
  • Build alignment and trust across leadership and cross-functional teams through clear, persuasive communication and collaborative engagement.
  • Mentor and elevate the data science community by championing best practices, nurturing talent, and cultivating a collaborative, high-performance culture.
  • Embody our culture and values