Twist Bioscience is seeking a Research Associate to support the evaluation, optimization, and advancement of cutting-edge Next-Generation Sequencing (NGS) solutions
Requirements
- Experience performing NGS library preparation, target enrichment, sequencing and familiarity with sequencing platforms (Illumina required; experience with PacBio or Oxford Nanopore a plus)
- Hands-on experience with DNA/RNA purification, library preparation, quantification (Qubit), PCR/qPCR, and electrophoretic QC (BioAnalyzer/TapeStation), enzymatic assays, and primer design
- Basic NGS data analysis knowledge (e.g., FastQ metrics, alignment QC metrics) and familiarity using Python, R, or similar tools for data visualization
- Experience with NGS applications such as WGS, RNA-Seq, and Metagenomics
- Experience with liquid handling systems and automation tools
- Familiarity with Illumina, PacBio, or Oxford Nanopore sequencing platforms
- Knowledge of molecular biology techniques such as enzymatic and mechanical library prep, DNA purification, PCR/qPCR
Responsibilities
- Perform a wide range of molecular biology techniques to support NGS workflow optimization (e.g., enzymatic and mechanical library prep, DNA purification, PCR/qPCR, QC using BioAnalyzer/TapeStation)
- Prepare samples to load sequencing runs and help manage sequencing outputs
- Assist in testing and optimizing NGS library preparation kits and sequencing workflows (e.g., Illumina, PacBio, Oxford Nanopore)
- Execute controlled experiments under the guidance of scientists, ensuring consistency, accuracy, and adherence to experimental plans
- Support post-launch product activities by helping analyze customer samples, participating in troubleshooting experiments, and generating data that informs technical documentation
- Contribute to drafting technical summaries, figures, and data packages for internal and external use
- Use tools such as Python, R, Jupyter notebooks, and common visualization packages to present data clearly
Other
- B.S. or M.S. in Molecular Biology, Biochemistry, Genomics, or related fields
- Ability to work collaboratively in a fast-paced, cross-functional R&D environment
- Clear communication skills
- Ability to manage multiple tasks/experiments and prioritize effectively
- Strong attention to detail, excellent organizational skills, and ability to follow SOPs and experimental protocols precisely
