The Arc Institute is seeking to develop next-generation platform technologies for genome engineering and biological programming to understand and treat complex human diseases.
Requirements
- Extensive experience with standard molecular biology techniques, including cloning, PCR, qPCR, NGS library preparation, and nanopore sequencing.
- Proficiency with mammalian cell culture and transfections.
- Experience with primary cells or iPSCs is a plus.
- Biochemistry experience (protein purification, in vitro transcription/mRNA purification) is a plus.
- Bioinformatics software experience is a plus (Geneious/SnapGene, Pymol/Chimera, Python).
Responsibilities
- Contribute to the discovery, development, and engineering of bridge recombinase systems.
- Utilize a wide array of high-throughput molecular biology techniques, such as Gibson and Golden gate assembly, DNA/RNA isolation, cDNA synthesis, qPCR/dPCR, NGS sample preparation, and more.
- Independently conduct tissue culture and transfection-based experiments, including flow cytometry and molecular readouts.
- Perform high throughput screening of libraries of RNA and protein variants.
- Assist with research planning, execution, analysis, troubleshooting, and data interpretation with a high degree of independence and continued support from the rest of the team.
- Analyze and present data at subgroup meetings and seminars.
- Maintain an organized and detailed lab notebook.
Other
- BS/MS or equivalent professional experience in cell & molecular biology, biochemistry or bioengineering
- BS degree, 2+ years of relevant experience or with a MS degree, 0-2+ years of relevant postgraduate experience
- Candidates with less experience but with requisite skills are encouraged to apply
- Highly motivated, curious, and a team player
- You love science and learning.
- You can work fast and are detail-oriented.
- You explicitly wish to use this experience to gain entry into a PhD program and are able to provide a minimum 2-year commitment to build a portfolio of work to support you in that endeavor.
- You love to collaborate and help others.
- You are a problem solver.
