Retro develops therapies for diseases driven by the biology of aging. We focus on cellular reprogramming and autophagy to broadly improve tissue function by targeting mechanisms of aging with the ultimate aim of adding 10 years to healthy human lifespan.
Requirements
- at least 2 years of hands-on experience generating, maintaining and characterizing iPSC lines.
- experience with gene delivery into primary cells ex vivo.
- Are familiar with good manufacturing practices or/and have experience working in a GMP environment.
- Have experience with process development and scaling iPSC production for cell therapies.
- Have experience in isolating cells from human samples.
- Have experience with cell characterisation techniques (eg FACS/flow cytometry, IF/microscopy, karyotyping).
Responsibilities
- Validate processes to generate iPSCs at scale and within clinically-driven time constraints.
- Generate and characterize iPSCs ensuring their high quality for preclinical safety studies.
- Perform primary cell isolation from patient’s starting material.
- Support tech transfer of iPSC protocols into GMP manufacturing.
- Contribute to establishing scalable manufacturing process of GMP-grade iPSCs.
- Maintain detailed and accurate records of experimental procedures and results.
- Generate and characterize iPSCs for clinical use.
Other
- Be part of a rotational weekend work schedule.
- Learn quickly and follow protocols precisely.
- Strive to continuously optimize practices for high speed and accuracy.
- Enjoy working cross-functionally with specialists with various backgrounds (cell biologist, quality control scientists, operational and logistic specialists).
- We are an equal opportunity employer; we do not discriminate based on race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
