Xaira Therapeutics is seeking to leverage AI to transform drug discovery and development by designing protein and antibody therapeutics against hard-to-drug molecular targets and developing foundation models for biology and disease to enable better target elucidation and patient stratification.
Requirements
- Proficient in Illumina sequencing library preparation methods for DNA and RNA, with a strong understanding of underlying biochemistry and assay design.
- Hands-on experience with Illumina sequencer operation and troubleshooting.
- Familiarity with single-cell workflows (e.g., 10x Genomics GEM-X) and/or 10x Genomics Flex assays is strongly preferred.
- Experience with quality control methods for nucleic acids and libraries (e.g., fragment analysis, fluorometric quantification, library quantification).
- Knowledge of high-throughput or automated NGS library prep platforms is a plus.
- Familiarity with cloud-based LIMS or data tracking systems (e.g., Benchling, BaseSpace) is a plus.
- Basic knowledge of NGS data analysis (e.g., demultiplexing, QC metrics interpretation, familiarity with sequencing file formats) is a plus.
Responsibilities
- Prepare high-quality sequencing libraries for Illumina platforms using a range of methods (e.g., TruSeq, Nextera, Amplicon, etc.).
- Operate and maintain Illumina sequencers (e.g., MiSeq, NextSeq, NovaSeq), including run setup, monitoring, troubleshooting, and basic maintenance.
- Support and execute single-cell workflows, including 10x Genomics GEM-X and 10x Flex assays.
- Perform QC of input material and libraries (e.g., Bioanalyzer, TapeStation, Qubit, qPCR) and assess data quality post-sequencing.
- Develop and optimize NGS protocols and contribute to the scaling of automated or high throughput sequencing pipelines.
- Running analysis pipelines (e.g., bcl2fastq, CellRanger, etc).
- Maintain detailed electronic lab notebook (ELN) records and ensure rigorous documentation for reproducibility and compliance.
Other
- B.S./M.S. in Molecular Biology, Genomics, Biotechnology, or a related field with 2+ years of laboratory experience, including direct experience in NGS workflows.
- Strong organizational skills and meticulous attention to detail in both benchwork and data documentation.
- Comfortable working in a fast-paced, collaborative environment, supporting multiple projects and stakeholders.
- Participate in group meetings and communicate experimental progress, challenges, and insights to broader teams.
