The University of Michigan Medical School is looking to elucidate the molecular and mechanistic aspects which underlie brain tumor growth, invasion, and the response to novel immune mediated therapeutics.
Requirements
- PhD in a recognized field of science related to the position
- At least 2 years of experience in a research setting relevant to the position
- Experience with Single Cell RNASeq, ChIP-Seq, ATAC-Seq, and advanced Bioinformatics
- Knowledge of immunological functional assays and 3D-multiplex immunohistochemistry
- Experience with gene therapy strategies, small molecules, and nanotechnologies
- Familiarity with research design and development of experiments and procedures
- Ability to work with novel therapeutic approaches in human clinical trials
Responsibilities
- Study the molecular and cellular mechanisms involved in tumor progression
- Investigate the role of the extracellular matrix on tumor growth and invasion
- Uncover the mechanisms which underpin immune mediated gene therapies, leading to tumor regression and anti-glioma immunological memory to prevent recurrences
- Utilize state-of-the-art omics technologies such as Single Cell RNASeq, ChIP-Seq, ATAC-Seq, as well as advanced Bioinformatics
- Learn immunological functional assays and 3D-multiplex immunohistochemistry to uncover cell-cell interactions and immune neighborhoods in the tumor microenvironment
- Develop and implement novel therapeutic approaches in human clinical trials for brain cancer
- Explore ways to translate research into novel Phase I clinical trials for GBM
Other
- A strong work ethic
- The ability to work independently, combined with a willingness to work in a highly interactive and collegial group
- Ability to provide significant input into the development of experiments, procedures and research design
- Ability to assist the principal investigator in determining research goals
- Must be eligible to work in the United States
