Novartis is seeking a Research Scientist specializing in histology to perform tissue-based analysis to support the discovery and validation of disease-relevant targets and pathways, primarily focusing on gene therapies.
Requirements
- Demonstrated experience in standard histological techniques.
- Experience with automated histology specific equipment is desirable.
- Knowledge of microscopy, image analysis and processing
- Thorough computer literacy (Word, Excel, PowerPoint and Graph Pad Prism and) is required.
- Prior experience in tissue-based assays including histology, in situ hybridization, immunohistochemistry, fluorescence applications and microscopy is desirable.
- Experience with automated histology specific equipment is desirable.
Responsibilities
- Sample receipt, logging and dissection of rodent samples.
- Perform standard histology procedures including tissue processing, embedding, sectioning, staining and image capture of formalin-fixed, paraffin-embedded tissues and cell lines.
- Perform specialized assays such as immunohistochemistry, immunofluorescence and in situ hybridization.
- Carry out automated assays on Ventana Discovery Ultra and Bond RX automated platforms.
- Process chromogenic and fluorescent slides for scanning using Leica AT2 and Akoya Vectra Polaris instruments.
- Perform image analysis and processing using Indica Labs HALO software.
- Generate quantitative data using Graph Pad Prism.
Other
- B.S. degree in biology, molecular biology, or related field.
- Record all experiments in electronic laboratory notebook.
- Participate in study planning with histology scientists and program team lead.
