Bristol Myers Squibb is seeking an experienced Research Scientist to generate and interpret data from in vitro and in vivo studies supporting nonclinical safety assessment for early Discovery candidates. The role involves investigative studies using in vitro models and New Approach Methodologies (NAMs) to assess toxicity and teratogenicity, as well as supporting in vivo studies with mechanistic investigations and pharmacodynamic assessments.
Requirements
- Hands-on experience with various analytical techniques such as Flow Cytometry, ELISA and PCR.
- Hands-on experience in cell culture methods including maintaining cell lines and primary cell isolation and culture.
- Advanced ability to create and completely understand, follow, interpret and apply SOPs for various in vitro assays.
- Advanced scientific writing and presentation skills including statistical analysis, data analysis and graphing, data presentation.
- Advanced problem-solving ability/mentality, technically adept and logical.
- Technical skills required include blood processing, tissue processing, protein analyses including ELISA and Luminex.
- Strong expertise in flow cytometry is highly desirable, including design and validation of novel multicolor panels, staining and analyzing diverse types of samples, as well as data analysis using Flowjo, FCS Express or similar, and with expertise using different types of flow cytometers and running high dimensional flow panels.
Responsibilities
- Evaluate toxicity and teratogenic liability assessments for early Discovery candidates including literature-based assessments, design and execution of investigative studies and reporting of these assessments.
- Apply molecular biology and flow cytometry expertise to develop and optimize assays for evaluating toxicity endpoints and Bio- / pharmacodynamic (PD) markers associated with investigative safety assessments and issue resolution.
- Apply approaches for functional assessment of drug targets or suspect off-targets such as siRNA, antisense oligonucleotides, and/or CRISPR.
- Apply expertise above with expertise in in vitro cellular and developmental model systems to conduct investigative mechanistic studies to characterize on- or off- target liabilities to support discovery programs.
- Apply multifaceted data analysis including use of specialized data analysis software for flow cytometry and gene or protein expression data.
- Study direct, execute, and report in vitro or in vivo studies evaluating toxicity or teratogenicity.
- Author internal reports and manuscripts associated with exploratory/investigative activities in scientific journals, present research work internally and at external conferences.
Other
- Ability to represent the interests of the group on cross-functional teams.
- Ability to work independently in a high-paced team environment, meet deadlines, and prioritize work from multiple projects.
- Advanced ability to communicate and collaborate effectively with peers, department management and cross-functional peers.
- Strong track record in large and/or small companies, contributing to innovative efforts within the laboratory setting to achieve defined goals and support clinical development, expertise in regulated environments & with clinical/diagnostic testing procedures is required.
- Create an atmosphere of scientific excellence, collaboration, open communication, and creativity in order to maximize productivity.
