Labcorp Genetics (formerly Invitae) is seeking a Research Scientist for functional assay development to support the Cellular Evidence Platform (CEP), a quantitative, scalable, and mechanistic assay that generates novel insight into how genetic variation may impact human health.
Requirements
- Technical knowledge of human genetics, next generation sequencing, and bioinformatics
- Deep domain expertise in next-generation sequencing applications, especially scRNA-seq, as well as first-hand experience with multiple sequencing platforms (i.e., Illumina and PacBio)
- Command of all standard molecular biology procedures, including recombinant DNA technologies, cloning, microbiology, and the manipulation and quantification of gene expression
- Bioinformatic skills sufficient for running the scripts that transfer and process large datasets
- Meticulous, creative and independent scientist with a proven track record of applying functional genomics technologies in mammalian cell systems
- Exceptional capabilities in mammalian tissue culture. Experience includes human iPSCs and immune cell types.
- Ability to use Python to run and debug bioinformatics pipelines for single-cell data analysis
Responsibilities
- Execute the CEP workflow, including variant library cloning, cell engineering, single-cell capture and cDNA synthesis, library preparation and sequencing, and data processing
- Creatively troubleshoot challenges with the experimental platform
- Collaborate with a cross-functional group of scientists, bioinformaticians, software engineers, and product managers
- Contribute to the management and maintenance of the research and tissue culture labs
- Communicate results to project leaders
- Maintain detailed and organized records within our ELN
- Foster a continually developing understanding of the practice and promise of functional variant modeling
Other
- PhD degree in biological science
- This position is not eligible for visa sponsorship
- Effective communication and presentation skills within the project team and to stakeholders
- Dedicated commitment to advancing our multidisciplinary team’s objectives
- Enthusiasm for working in collaborative and cross-disciplinary environments
