Iambic Therapeutics is looking to accelerate and strengthen their drug discovery programs by designing, optimizing, and executing high-throughput experiments to drive compound library campaigns using their HTE platform.
Requirements
- Strong background in organic synthesis, catalysis, and reaction development
- Strong command of modern organic synthetic methods
- Direct hands-on experience with High Throughput Chemistry and/or Parallel Synthesis.
- Experience with laboratory automation, liquid handling robotics, and automated analytical and purification systems.
- Experience with Direct-to-Biology (D2B) strategies for drug discovery.
- Familiarity with the principles of medicinal chemistry
Responsibilities
- Design and execute parallel synthetic methods to generate large, high-quality compound libraries.
- Identify, develop, and optimize novel synthetic methodologies with a focus on automation compatibility and HTE scalability.
- Apply newly developed synthetic routes from traditional bench-scale chemistry to robust, high-throughput, and automated processes.
- Oversee the operation, maintenance, and continuous advancement of our chemistry toolkit and automated synthesis equipment.
- Analyze research outcomes and library compound data and clearly communicate results and findings to cross-functional project teams.
- Ensure all laboratory work is conducted in accordance with established safety protocols and best laboratory and ELN data recording practices.
- Proactive problem-solving mindset leveraging attention to detail and available resources to identifying bottlenecks, troubleshooting automated processes, and developing solutions to ensure business continuity.
Other
- Collaborate cross-functionally with chemistry, biology, compound management, AI/ML, and software teams across the discovery pipeline
- A strong commitment to teamwork and the ability to function effectively as a core member of an interdisciplinary scientific team (chemistry, biology, software, and automation).
- Ability to thrive in fast-paced, highly collaborative, and dynamic research environment.
- Excellent written and verbal communication skills; must be able to articulate complex scientific concepts, technical challenges, and results clearly and concisely to diverse audiences.
- Proven ability to thrive in a fast-paced, high-volume environment where priorities and synthetic targets may shift rapidly based on biological data.
- Ability to mentor junior scientists
