GenScript is looking to improve its proprietary semiconductor DNA synthesis technology and develop various diagnostic applications.
Requirements
- Expertise in nucleoside, nucleotide, and solid-phase oligonucleotide synthesis.
- Strong foundation in organic chemistry and photochemistry.
- In-depth understanding of nucleic acid chemistry and phosphoramidite-based synthesis.
- Hands-on experience with total synthesis, including a variety of purification techniques such as column chromatography, HPLC, and Biotage systems.
- Advanced molecular biology skills, including PCR, qPCR, hybridization assays, and next-generation sequencing (NGS).
- Familiarity with laboratory automation tools and platforms (a plus).
- Demonstrated proficiency in handling sensitive or delicate materials (preferred).
Responsibilities
- Develop and synthesis of desired organic compound
- Select and employ analytical techniques for synthesized compound
- Develop and perform on machine oligo synthesis with various modifications
- Develop surface functionalization for metal and non-metal surfaces for solid phase oligonucleotide synthesis
- Select and employ analytical techniques for surface characterization
- Explore methods toward enhancing surface stability and functional loading
- Contribute knowledge and expertise in the field of nucleic acid chemistry, specifically phosphoramidite based oligonucleotide synthesis.
Other
- Ph.D. in Organic Chemistry, Biochemistry, Chemical Biology, or a related field; or M.S. with a minimum of 3 years of relevant industry experience.
- Proven track record of effective collaboration within interdisciplinary and cross-functional teams.
- Results-driven, with a proactive, hands-on approach to experimental design and problem-solving.
- Excellent written and verbal communication skills.
- Strong documentation skills for drafting technical reports, summarizing experimental data, and supporting technology transfer to manufacturing.
