Novartis is seeking a Research Scientist II to establish and advance their oligonucleotide synthesis laboratory for xRNA therapeutics, focusing on synthesizing, purifying, and characterizing therapeutic oligonucleotides and designing novel nucleoside phosphoramidites.
Requirements
- organic chemistry, particularly in nucleoside & oligonucleotide synthesis, purification and characterization
- Familiarity with using automated SPOS (solid phase oligonucleotide synthesis) for therapeutic oligonucleotide synthesis
- Proficiency with purifying, analyzing and characterizing therapeutic oligonucleotides with LC/HRMS, RP-HPLC, AEX-HPLC, SEC-HPLC and UV-vis analytics.
- Basic understanding of RNA therapeutics and their role in biology
- Prior experience with oligonucleotide bioconjugation is a plus
Responsibilities
- Synthesize, purify, and characterize therapeutic oligonucleotides using automated oligonucleotide synthesizers such as Shasta, K&A, or Mermade
- Maintain standard operating procedures (SOPs) for synthesis, processing, and purification of therapeutic oligonucleotides to ensure reproducibility.
- Design and synthesize novel nucleoside phosphoramidites for incorporation into therapeutic oligonucleotides
Other
- This position will be located at the Cambridge site and will not have the ability to be located remotely.
- Bachelors degree in a scientific discipline with at least 2 years of experience
- Master’s degree is preferred.
- Be a team player prepared to work in a collaborative, fast-paced environment
