Revolution Medicines is looking to develop novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.
Requirements
- A strong theoretical understanding of the core concepts, assumptions, and limitations associated with PK/PD modeling
- Experience with development, calibration, and validation of ordinary differential equation (ODE) and non-linear mixed effect (NLME) models.
- Solid PK/PD knowledge and prior experience with PK/PD data collection and analysis.
- Hands on experience with modeling software (Simbiology, Phoenix WinNonlin, NONMEM, etc.) and PBPK model development.
- Demonstrated experience in in vivo experiments with oncology disease models.
Responsibilities
- Develop, validate and refine physiologically-based PK (PBPK), quantitative systems pharmacology (QSP), and semi-mechanistic PK/PD models to support discovery and development-phase projects.
- Propose mechanistic in vitro and in vivo experiments to test model assumptions and structure.
- Design, conduct, and manage in vivo and ex vivo experiments in-house or at contract research organizations (CROs), and other collaborating institutions, to support above modeling activities
- Develop high-quality protocols and outputs and maintain detailed documentation of procedures and data to comply with internal standard operating procedures and other quality criteria, where necessary.
- Present results at internal meetings and scientific conferences.
Other
- Ph.D. with quantitative science background (pharmaceutical sciences, mathematics, systems pharmacology, computational biology, etc.); or Ph.D. in pharmacology or cancer biology or a related discipline with modeling experience.
- 2+ years of relevant postdoc or industry experience in cancer drug discovery and development.
- Excellent written and verbal communication skills.
- Demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important.
- Thrives in a collaborative team setting and is driven by a desire to be innovative in a dynamic and fast-paced environment.
