Bristol Myers Squibb's Oncology Thematic Research Center is seeking to discover and develop novel oncology therapeutics for patients with tumors refractory to current therapies. This role will support translational research lab-based activities to enable the development of transformative cancer therapies.
Requirements
- Experience performing laboratory work, including cell culture and isolation of primary immune cells.
- Experience designing and validating novel biomarker assays for proof-of-concept, suitable for deployment in early-phase clinical trials.
- Experience performing analysis of protein, DNA, and RNA samples using a variety of methodologies including but not limited to: flow cytometry, MSD/ELISA, Western blot, qPCR, and functional assays.
- Proficient in translational research encompassing biomarker identification, PK/PD and efficacy correlations, and dose estimation
- Have familiarity with commonly utilized in vitro oncology and cancer immunology models and assays.
- Use current and new techniques to characterize drug mechanism of action and resistance.
- Develop biomarker, pharmacodynamic and target engagement assays.
Responsibilities
- Develop biomarker, pharmacodynamic and target engagement assays.
- Use current and new techniques to characterize drug mechanism of action and resistance.
- Have familiarity with commonly utilized in vitro oncology and cancer immunology models and assays.
- Experience performing laboratory work, including cell culture and isolation of primary immune cells.
- Execute experiments independently, troubleshoot as needed, analyze, interpret and discuss data.
- Design and execute preclinical studies to inform indication selection, patient enrichment, rational combination strategies, and selection of biospecimen collection timepoints
- Experience performing analysis of protein, DNA, and RNA samples using a variety of methodologies including but not limited to: flow cytometry, MSD/ELISA, Western blot, qPCR, and functional assays.
Other
- The qualified candidate is a highly motivated, engaged, and organized scientist that can thrive in a highly matrixed organization.
- Have excellent time management skills and the ability to conduct experimental work independently, with accurate, detailed record-keeping.
- Display excellent communication, presentation and interpersonal skills.
- Collaborate closely with fellow translational research scientists, actively sharing expertise and ensuring smooth information exchange across programs and portfolios to strengthen teamwork and drive scientific advancement.
- Ability to effectively collaborate with internal and external partners (e.g. CROs, specialty labs, etc.)
