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Senior Lead Machine Learning Engineer

Upwork

$195,000 - $296,000
Oct 9, 2025
Remote, US
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Upwork is seeking a Senior Lead Machine Learning Engineer to shape the future of AI-powered intelligence, leading the design and delivery of infrastructure and models that support agentic LLM workflows across the platform.

Requirements

  • Demonstrated expertise in building, deploying, and scaling advanced ML models in a production environment using Python and frameworks like PyTorch or TensorFlow.
  • Deep technical understanding of transformer-based models, generative AI, and agent architectures such as MCP or A2A.
  • Proven experience training and optimizing large models on GPU clusters and integrating LLMs with APIs or orchestration systems.

Responsibilities

  • Design and implement resilient infrastructure for agentic LLM systems, including multi-agent coordination, Retrieval-Augmented Generation (RAG), and real-time orchestration.
  • Lead training and fine-tuning of large-scale foundation models tailored to Upwork’s domain-specific challenges and user base.
  • Partner with engineering, product, and research teams to align technical development with strategic business priorities.
  • Mentor and support other engineers and researchers to elevate team-wide technical capabilities and foster a culture of innovation and inclusion.
  • Drive experimentation and translate findings into robust, scalable production systems with clear metrics of success.
  • Identify opportunities for innovation, challenge conventional approaches, and lead initiatives that push the boundaries of applied ML.
  • Contribute to the external AI/ML community through papers, talks, or open-source contributions, enhancing Upwork’s visibility in the field.

Other

  • Bachelor's, Master's, or Ph.D. degree in Computer Science, Machine Learning, or related field (not explicitly mentioned but implied)
  • Collaborative mindset, clear communication skills, and a drive to mentor and elevate those around you.
  • Track record of leading high-impact, cross-functional initiatives with a focus on business outcomes and customer value.
  • Must be eligible to work in the United States (implied due to mention of U.S. states and California Fair Chance Act)
  • Criminal background check may be required once a conditional job offer is made.