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Senior Machine Learning Engineer

Definitive Healthcare

Salary not specified
Aug 26, 2025
Remote, US
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Definitive Healthcare is looking for a Senior Machine Learning Engineer to lead the design and implementation of cutting-edge AI/ML systems that deliver transformative business outcomes, aiming to improve customer experience and operational efficiency.

Requirements

  • Deep expertise in Python, SQL, and PySpark for distributed data processing, with proficiency in libraries like scikit-learn, PyTorch, and XGBoost.
  • Proven experience designing robust ML pipelines, leveraging tools like MLflow or equivalent.
  • Strong command of ML frameworks (e.g., scikit-learn, TensorFlow, XGBoost, PyTorch).
  • Hands-on experience deploying models in cloud-based environments (AWS, GCP, Azure, and Databricks).
  • Proven ability to manage end-to-end ML lifecycles at scale, including data ingestion, training, evaluation, deployment, and monitoring.
  • Strong knowledge of MLOps practices including CI/CD for ML, automated retraining, and model versioning.
  • Experience with deep learning architectures for time series forecasting, sequential data, or hierarchical modeling.

Responsibilities

  • Lead the design and implementation of scalable, production-grade ML systems in cloud environments with a focus on performance, reliability, and reproducibility.
  • Oversee the architecture and evolution of data pipelines for multi-terabyte datasets, ensuring efficiency and reliability.
  • Guide the development of high-impact features and label sets across diverse domains such as healthcare and consumer analytics
  • Lead experimentation strategy, including design of A/B tests, advanced validation methods, and lifecycle management using tools like MLflow and Databricks.
  • Drive continual model improvement through advanced techniques such as automated retraining, model decay analysis, and bias mitigation.
  • Champion rapid prototyping and proof-of-concept development to evaluate emerging technologies and ML techniques.
  • Lead technical explorations into new ML architectures (e.g., foundation models, causal inference, time series deep learning).

Other

  • Collaborate with product managers and senior stakeholders to define and prioritize ML initiatives aligned with business goals.
  • Serve as a technical leader and trusted advisor, working closely with product, engineering, data, and executive teams to shape end-to-end ML solutions.
  • Set standards for code quality, performance, and documentation, and mentor junior engineers in best practices
  • Excellent communication skills and demonstrated ability to influence cross-functional teams.
  • Comfortable operating in fast-paced, high-ownership environments, and able to prioritize multiple high-impact projects