FL94 Inc. is a biotechnology company pioneering Protein Editing, aiming to create small molecules that edit protein structure and function to unlock undruggable targets and develop new therapeutic modalities. The company seeks to integrate chemistry, chemoproteomics, and ML for generative design, backed by Flagship Pioneering to move from platform validation to patient impact.
Requirements
- Hands-on experience with one or more of the following techniques: HPLC, UV-visible, DSC etc
- Experience with data analysis using standard software platforms (Excel, Prism etc.)
- Practical experience in developing and preparing preclinical formulations (small molecules)
- Basic knowledge of physicochemical properties and their relationship to formulation development
- Basic knowledge of pharmacokinetics (PK) and biopharmaceutics principles
Responsibilities
- Execute stage appropriate, fit-for-purpose preclinical formulations preparation (Solutions, suspensions, emulsions, nanoparticles, SEDDS etc.) for oral, and parenteral formulations on a small scale for small molecules
- Author protocols describing preparation of formulations for use at internal and external formulation labs
- Basic drug substance characterization by using techniques such as HPLC/UPLC, XRPD, DSC and PLM. Assessment of the chemical and physical properties of small molecules, such as solubility, dissolution, particle size and chemical stability
- Routine lab support such as buffer and mobile phase preparation, pH meter calibration, basic troubleshooting of lab equipment, and coordinating with external instrument and service vendors. Shipping and receiving samples between internal and external sites
- Summarize experimental results and presents at team meetings and department presentations
- Author templated memos and reports with limited guidance
- Evaluate novel drug delivery systems (e.g., lipid-based, amorphous solid dispersions, spray dry etc.) for poorly soluble compounds
Other
- S. or M.S. in Chemistry, Biochemistry, Chemical Engineering, or a related discipline is required
- ONE (1) year (minimum) industry, government or equivalent experience in small molecules formulation or a related field
- The ability to manage multiple parallel activities and deliver results to agreed timelines
- Ability to do bench work independently
- Strong collaboration, problem-solving, and adaptability in fast-paced research environments
- Excellent written, oral, and visual communication skills
- Excellent time management skills
