Profluent is seeking to solve the problem of discovering, characterizing, and engineering novel gene editing proteins to revolutionize biomedicine
Requirements
- Hands-on experience in protein engineering
- Hands-on experience with mammalian genome editing and mammalian cell culture
- Expertise in high throughput screening (mammalian, microbial, and/or in vitro)
- Hands-on experience with NGS-based assays
- Hands-on experience with molecular cloning
- In-depth knowledge of DNA repair and methods to analyze DNA repair outcomes
- Deep understanding of design and execution of NGS-based assays
Responsibilities
- Working closely with bioinformatics, machine learning, and automation, lead cross-functional campaigns to discover, characterize, and engineer proteins for DNA manipulation
- Design, execute, and automate robust cell-based and biochemical workflows for the characterization and engineering of novel gene editing tools
- Develop and validate assays to measure on- and off-target activity of novel gene editing systems using a combination of targeted and genome-wide analytical methods
- Analyze data to inform critical go/no-go decisions, and clearly present conclusions and rationale to stakeholders across the organization
- Stay up to date on the latest developments in gene editing technology
Other
- Bachelor's degree in molecular biology, biochemistry, or a related field with 4-8 years of relevant experience, or Master’s degree with 2-6 years of relevant experience
- Excellent communication skills to communicate data and project updates across teams with diverse technical backgrounds
- Proven track record of successfully delivering on ambitious research projects
- Applicants must have ongoing work authorization in the United States that does not require employer sponsorship
- Legal authorization to work in the United States is required
