FL94 Inc. is seeking to develop first-in-class medicines and new chemical modalities for autoimmune and inflammatory diseases by leveraging a novel protein editing platform that integrates small molecule chemistry, chemoproteomic discovery, and Machine Learning.
Requirements
- Sound knowledge of disciplines involved in drug discovery (cell-based disease models, target engagement and target modulation assays, cell viability assays, biomarker discovery, PD/PK and efficacy studies)
- Comfort in independently executing immune phenotypic and functional assays, such as multicolor flow cytometry, proliferation assays, and cytokine detection.
- Expertise in molecular biology techniques- WB, RT-qPCR, FACS, cloning, cell culture, gene KO/KI using CRISPR/CAS9, siRNA and/or shRNA, over-expression using Lenti viral transduction.
- Some in vivo experience with dosing and autoimmune disease models preferred.
- Competency in using data processing software (Graph Pad Prism, Spotfire, Dotmatics, etc).
Responsibilities
- Develop appropriate in vitro cellular assays to screen small molecules.
- Develop and execute functional assays with primary murine or human immune cells to support mechanism of action studies, characterize on-target and off-target pathway modulation.
- Design and perform immune functional and phenotypic assays, such as cytokine quantification, proliferation assays, and intracellular flow cytometry.
- Manage execution of in vivo studies in collaboration with an external CRO
- Analyze data and prepare presentations for discussion at team meetings
- Review targets identified by our platform for potential as therapeutic targets.
- Build a robust infrastructure of laboratory protocols, tools, and systems that will scale efficiently.
Other
- Master’s degree with 4+ years of working experience in molecular biology, cellular biology, immunology, or related fields.
- Desire to work within highly skilled teams in a fast-paced, quickly evolving technical environment.
- Excellent communication and presentation skills, capable of conveying scientific information in a concise and effective manner.
- Successful candidates will be able to thrive in a fast-paced, action-oriented, team environment and lead from the bench.
- Work collaboratively in cross-functional teams with chemistry, proteomics, drug discovery and AI/machine learning
