Stoke Therapeutics is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. The company is seeking a Senior Research Associate to join their Early Development team focused on oligonucleotide-based therapeutics, contributing to the design and development of innovative drug formulations at the preclinical and early clinical stages.
Requirements
- Prior industry experience in oligonucleotide formulation and scale-up is desired
- Sound knowledge of analytical chemistry and basic nucleic acid chemistry is preferred
- Experience with UPLC, LCMS and formulation characterization instrument is desired
- Hands-on experience with lab techniques such as pH adjustment, UV spectroscopy, endotoxin and physical property measurement; hand-on experience with HPLC/UPLC is a plus
Responsibilities
- Support the design and execution of formulation studies for oligonucleotide drug products
- Perform laboratory experiments in a safe and efficient manner and record research findings in ELN
- Collaborate with analytical, process development, and manufacturing teams to ensure seamless tech transfer
- Support analytical testing and interpretation of data related to physical and chemical stability
- Contribute to the preparation of technical reports, presentations, and regulatory documentation
- Stay current with scientific literature and industry trends in oligonucleotide formulation and delivery
Other
- B.S. with 4 years of experience or M.S. with 2 years of experience in Chemistry or Organic Chemistry
- Strong organizational skills and attention to detail
- Excellent communication and teamwork abilities
- This position will require approximately 5% travel.
- This position is a lab-based position in our Bedford, MA location.
