Stoke Therapeutics is developing RNA medicine, specifically antisense oligonucleotides (ASOs), to restore protein expression for diseases caused by a loss of normal protein levels. The company is seeking a Senior Research Associate to support the design and development of innovative drug formulations for oligonucleotide-based therapeutics at the preclinical and early clinical stages.
Requirements
- Prior industry experience in oligonucleotide formulation and scale-up is desired
- Sound knowledge of analytical chemistry and basic nucleic acid chemistry is preferred
- Experience with UPLC, LCMS and formulation characterization instrument is desired
- Hands-on experience with lab techniques such as pH adjustment, UV spectroscopy, endotoxin and physical property measurement; hand-on experience with HPLC/UPLC is a plus
Responsibilities
- Support the design and execution of formulation studies for oligonucleotide drug products
- Perform laboratory experiments in a safe and efficient manner and record research findings in ELN
- Collaborate with analytical, process development, and manufacturing teams to ensure seamless tech transfer
- Support analytical testing and interpretation of data related to physical and chemical stability
- Contribute to the preparation of technical reports, presentations, and regulatory documentation
- Stay current with scientific literature and industry trends in oligonucleotide formulation and delivery
Other
- This position is a lab-based position in our Bedford, MA location.
- This position will require approximately 5% travel.
- Strong organizational skills and attention to detail
- Excellent communication and teamwork abilities
- B.S. with 4 years of experience or M.S. with 2 years of experience in Chemistry or Organic Chemistry
