Stoke Therapeutics is seeking a senior research associate in oligonucleotide chemistry to support the development of oligonucleotide-based therapeutics, specifically for diseases of the central nervous system and the eye caused by haploinsufficiency.
Requirements
- Hands-on experience with Oligo synthesis (mid and large scale preferred).
- Experience with MerMade 12 and 192 synthesizers preferred.
- Experience in preparing buffers for purification and maintaining lab instruments such as AKTA purifiers, UF, HPLC and LC-MS.
- Previous experience using Microsoft Excel, Word, PowerPoint and Chemdraw
- BS. with 4 years of experience or M.S. with 2 years of relevant industry experience
- Experience with solid phase chemical synthesis of oligonucleotide, conjugation, HPLC purification, and LC-MS analysis
Responsibilities
- The role is primarily responsible for supporting the automated synthesis, cleavage, deprotection, purification, analysis and packaging of oligonucleotides, including heavily modified oligonucleotides.
- Maintaining laboratory equipment, including the oligonucleotide synthesizer, HPLC machines and benchtop equipment to ensure consistent and reliable oligonucleotide production.
- Performing critical evaluation and optimization of the processes to improve synthesis yield, purity and timelines for production of modified oligonucleotides
- Manage ordering and organization of chemicals and supplies necessary for oligonucleotide synthesis
- Analyzing and interpreting data as well as writing technical reports and protocols, with supervision.
- Presents research results at lab meetings.
- Keeps up to date on relevant scientific literature and developments to support ongoing research efforts.
Other
- BS. with 4 years of experience or M.S. with 2 years of relevant industry experience
- Travel: This position will require approximately 5% travel.
- Degree requirements: BS or MS in a relevant field
- Work arrangement: flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business
- Diversity, Inclusion, and Belonging: Stoke is committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us.
