BeOne is seeking a Senior Bioinformatics Scientist to enhance its bioinformatics capabilities in the United States to support clinical biomarker analysis and translational research, aiming to accelerate the fight against cancer.
Requirements
- Proficient in programming and scripting with R, along with the expertise in at least one other programming language (e.g., Python, Perl, Java).
- Skilled in working with Linux systems and server/cloud computing environments.
- Extensive experience in analyzing high-throughput biomedical data (e.g., RNASeq, scRNAseq, WES, spatial gene expression profiling, or human genetics): including data cleaning, functional annotation, normalization, interpretation, and visualization.
- Familiarity with tools for reproducible research such as Git, Conda, Snakemake, or Nextflow.
- Proven expertise in clinical biomarker analysis, with a particular focus on Omics biomarker data for Oncology and Immunology-related drug discovery and development.
- Solid background in statistics and mathematics; experience with machine learning/AI is a plus.
Responsibilities
- Serve as the lead bioinformatics scientist of the internal drug discovery and development programs, providing comprehensive support for new target exploration and validation, Omics-related experiment design and analysis, clinical biomarker testing platform and vendor selection, and clinical biomarker analysis with interpretation.
- Design, develop, and deploy robust bioinformatics workflows and interactive tools to analyze high-dimensional Omics data, with an emphasis on bulk and single-cell transcriptomes, whole-exome sequencing (WES), and proteomes data.
- Collaborate with the IT team to build and maintain the bioinformatics computing and analysis infrastructure.
- Mine proprietary and public biological and biomedical data to generate novel hypotheses or insights, and propose the follow-up validation plans
- Work closely with research scientists and the global biomarker and translational research team, adhering to sound scientific practices and maintaining effective documentation of activities and analyses.
- Present analytical results in a clear and concise manner, utilizing well-designed presentation materials.
Other
- Highly motivated, collaborative, and share a passionate interest in fighting cancer.
- Excellent communication skills to facilitate international and cross-functional collaboration.
- Strategic thinker, self-motivated, and adept at working collaboratively within an international and dynamic environment, consistently mindful of timelines.
- Quick learner, enthusiastic about taking on new challenges.
- Fluent in Mandarin required to collaborate with Mandarin-speaking stakeholders in China and review Mandarin-language technical documentation.
