AstraZeneca's In vitro Discovery Platforms group within the Biologics Engineering department is pushing the boundaries of science to deliver life-changing medicines by exploring novel therapeutic approaches across various diseases. The job is to plan and execute experiments focused on isolating, engineering, and characterizing antibody and antibody-like therapeutics, and to contribute to technology platform builds and streamline discovery workflows.
Requirements
- Familiarity with handling large datasets; data science skills including coding and script writing
- Extensive and current hands-on experience with phage and yeast-display technology for antibody discovery
- Proven hands-on experience with sample prepping for NGS data generation and sequence analysis
- Experience in Sanger sequence analysis, protein expression and purification, ELISA, flow cytometry, and tissue culture
- Experience working with various antibody formats including VHH, scFv and Fab
- Transfection/electroporation, culturing and expansion of mammalian cells
- Experience with electronic notebook keeping and data entry using Genedata Biologics
Responsibilities
- Complete wet-lab experiments (80%) and data analysis for hit selection and characterization (20%)
- Independently design and execute discovery campaigns using phage and yeast-display technologies
- Recover yeast plasmids and prepare samples for NGS data generation
- Analyze NGS data with appropriate software, e.g. Geneious Biologics/MixCR, and select hit lists for small scale antibody production
- Contribute to technology platform builds and streamline discovery workflows using phage/yeast display VH, scFv and Fab libraries
- Interpret and present data as a lead scientist/co-lead in the context of multidisciplinary project teams
- Work within a matrixed environment across multiple groups
Other
- Master’s Degree in Biochemistry, Data Science or related fields with 7+ years of proven experience in industry (preferred) or academia
- Doctoral Degree with 0-2 years of proven experience in industry (preferred) or academia
- Ability to work independently and in a team setting
- Self-motivated, diligent, and flexible in accommodating shifting priorities
- Strong communication and interpersonal skills, both oral and written, with supervisor, team, and various cross-functional project team members
