AbbVie is seeking a highly motivated person to join the Biologics CMC Developability Team to support the early-stage assessment of candidates coming out of the Discovery pipeline with the opportunity to influence the design and development of stable drug product formulation and manufacturing processes for biologics used in clinical trials.
Requirements
- Leverage mass spectrometry and other advanced characterization techniques to support the early-stage assessment of candidates coming out of the Discovery pipeline
- Deep understanding of protein stability characterization (e.g., SEC, IEX, HIC, CE)
- Additional robotics expertise and digital data capture experience is beneficial
- Knowledge of functional excipient degradation pathways is a plus
- Solid understanding of the scientific approaches to develop commercially viable protein drug products
Responsibilities
- Lead developability assessment activities, including candidate screening and selection for clinical studies of monoclonal antibodies, antibody drug conjugates, bispecifics, and fusion proteins.
- Utilize analytical instruments to understand structural stability of biotherapeutic entities to influence candidate protein sequence design and selection.
- Develop independent research ideas and pursue scientific questions to continually improve developability approaches.
- Present data at internal and external professional conferences and prepare manuscripts for publication in peer reviewed journals or patent applications.
- Build and manage strategic alignments with key stakeholders, revise and improve business workflows, manage project timelines and resources.
- Develops the optimal CMC development path for assigned discovery projects together with clients from various R&D functions with an emphasis on collaboration, quality and with a sense of urgency.
Other
- Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance.
- Excellent oral communication skills in a scientific setting as well as sound technical writing and documentation competencies are required.
- The candidate must be able to work independently, respond to changing priorities and short lead times for multiple tasks; able to identify problems and work toward solutions.
- Raises the bar and is never satisfied with the status quo.
- Creates a learning environment, open to suggestions and experimentation for improvement.
