FL108 Inc., a biotechnology company, is focused on developing novel protein-based delivery modalities to improve patient care. The position aims to solve the challenge of designing and implementing advanced computational protein design techniques to support FL108's mission, backed by Flagship Pioneering.
Requirements
- Ph.D. (with 2+ yrs of industry research experience) in computational protein design, protein biochemistry, computational biophysics, computational biology, physics, or related field
- Expertise in computational protein modeling and design, structural biology, and biophysics is required
- Deep expertise with ML tools for computational protein design such as AlphaFold, RosettaFold, ESMFold, ProteinMPNN, RFDiffusion, Chroma, IgFold, DeepAb, Parapredis is required
- Experience with antibody and/or nanobody modeling and design is strongly preferred
- Knowledge of critical wet-lab techniques used in protein engineering such as phage display, SPR, ITC, CD-spectroscopy is preferred
Responsibilities
- Drive the AI/ML computational protein design
- Engage with Pioneering Intelligence at Flagship to explore and implement novel ML models that benefit FL108 design principles
- Advance both antibody engineering and de novo antibody design pipelines
- Collaborate closely with the Fl108 experimental scientists to test and iterate on constructs
- Engineer novel functionalities into protein scaffolds, leveraging structural modeling, rational design, and/or directed evolution
- Be abreast of the computational protein design field to advise design and strategic directions for protein engineering, implementing the latest technologies where necessary
- Contribute to strategic direction of the computational team at FL108, helping shape our design platform at the forefront of scientific innovation
Other
- Ph.D. (with 2+ yrs of industry research experience) in computational protein design, protein biochemistry, computational biophysics, computational biology, physics, or related field
- Strategic thinker, able to shift seamlessly between rigorous scientific details and high-level context and implications
- Instinctive team player with excellent communication skills and great attention to detail
- Equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status
- Ability to work in a fast-paced, entrepreneurial, and highly collaborative start-up environment
