Legend Biotech needs a Head of Translational Research to lead the translational sciences group, providing biomarker support for their pipeline development in cell and gene therapy, ultimately aiming to improve patient selection, understand drug mechanisms, and identify key product characteristics.
Requirements
- PhD or MD in biology, immunology, biochemistry or related field
- In depth Knowledge of immunology and tumor biology
- Strong background in clinical biomarker analysis, research tools, technology and assay platforms
- At least 10 years of experience in pharmaceutical or biotech industry
- Experience in cell therapy clinical development is preferred.
- Knowledge and experience in CDx development are plus
Responsibilities
- Lead translational team, and provide preclinical and clinical translational support for Legend pipeline development
- Establish translational biomarker strategy in alignment with clinical development objectives
- Lead translational safety investigation, develop MOA hypothesis and identify key characteristics relevant to efficacy and treatment failure
- Work closely with clinical and regulatory teams in investigator brochures, IND applications, clinical protocols, and other clinical and regulatory documents when appropriate
- Accountable for patient selection strategies, CDx development, approval and implementation
- Provide oversight and management to CROs and academic collaborations
- Collaborate with discovery, preclinical development, CMC and clinical teams to accelerate the product pipeline
Other
- At least 15 years of relevant work experience
- Excellent communication and writing skills
- Ability to work effectively and collaboratively in cross functional teams
- Language: English
